Nimbus Wiki

A comprehensive guide to how the immune system processes and displays antigens to T cells through MHC molecules, enabling adaptive immune responses.

A comprehensive guide to the human leukocyte antigen system, including genetics, structure, function, and clinical significance in disease and transplantation.

A comprehensive guide to how the immune system evolves increasingly potent antibodies through iterative cycles of mutation and selection in germinal centers.

A comprehensive guide to how B cells assemble unique antibody genes through V(D)J recombination at the immunoglobulin heavy and light chain loci.

A comprehensive guide to the specialized microanatomical structures where B cells undergo affinity maturation, class switching, and memory formation during T-dependent immune responses.

A comprehensive guide to how B cells evolve higher-affinity antibodies through targeted mutation in germinal centers, including the molecular mechanisms, regulation, and clinical significance.

A comprehensive guide to B lymphocyte development, from hematopoietic stem cells in the bone marrow through mature B cell subsets in the periphery.

A comprehensive guide to how the immune system distinguishes self from non-self and prevents autoimmunity through central and peripheral tolerance mechanisms.

A comprehensive guide to T lymphocyte development in the thymus, including stages of maturation, TCR rearrangement, positive and negative selection, and lineage commitment.

A comprehensive guide to the complete collection of T cell and B cell receptors in an individual, including diversity metrics, clonality analysis, and clinical applications.

A comprehensive guide to the molecular mechanism that generates immune receptor diversity through somatic recombination of variable, diversity, and joining gene segments.

How immune repertoire sequencing enables new diagnostic approaches for autoimmune diseases, from HLA-B27 spondyloarthropathy to celiac disease.

How immune repertoire sequencing enables sensitive detection of minimal residual disease in lymphoma, leukemia, and multiple myeloma.

Using immune repertoire sequencing to monitor rejection risk, immune reconstitution, and tolerance in solid organ and hematopoietic stem cell transplantation.

A comprehensive guide to the molecular architecture of the T cell receptor, including alpha and beta chains, complementarity-determining regions, and the mechanisms of antigen recognition.

A comprehensive guide to technologies for sequencing T cell and B cell receptors, from bulk methods to single-cell approaches.

Definitions of key terms in adaptive immunology, immune repertoire sequencing, and immunodiagnostics.

A curated collection of databases, software tools, educational materials, and community resources for adaptive immunology research.