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Moose

De novo discovery of sequence motifs in TCR and antibody repertoires using R.

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Installation

R: devtools::install_github("BorchLab/moose")

Moose is a motif-discovery and statistical framework for adaptive immune receptor repertoires. It identifies enriched sequence motifs, quantifies their statistical significance, and supports cluster- or condition-specific motif enrichment analysis.

Key Features

  • Identification of enriched motifs in TCR/BCR repertoires
  • Statistical testing across clusters, samples, or disease states